The manga is set thirteen years after the end of Marmalade Boy, and focuses on Ritsuka Matsuura and Saku Koishikawa; Yuu and Miki's respective sister and brother. Many of the characters from the original series will appear gradually as it continues.
- The daugther of Youji and Rumi Matsuura and half-sister of Miki and Yuu. Marmalade Boy Little centers around her and Hajime.
- Aoi Namura
- Aoi is the son of Meiko Akizuki and Shinichi Namura
- Main article: List of Marmalade Boy Little chapters